Genetic inheritance is a basic principle of genetics and explains how characteristics are passed from one generation to the next.
Genetic inheritance occurs due to genetic material, in the form of DNA, being passed from parents to their offspring. When organisms reproduce, all the information for growth, survival, and reproduction for the next generation is found in the DNA passed down from the parent generation.
Much of our understanding of inheritance began with the work of a monk by the name of Gregor Mendel. His experiments and ‘Laws of Inheritance’ provide the foundations for modern genetics.
In sexual reproduction, the genetic material of two parents is combined and passed on to one individual. Although the offspring receives a combination of genetic material from two parents, certain genes from each parent will dominate the expression of different traits.
Mendel is accredited as the first person to correctly understand the process of how characteristics are inherited by offspring from parents. Before Mendel, many other incorrect hypotheses attempted to explain how characteristics and traits were passed from generation to generation. The most commonly accepted theory was the ‘blending theory’ which proposed that the traits of parents were blended together and an intermediate trait was expressed in the offspring. Mendel’s work on the common pea plant proved that was not the case.
Mendel performed a series of rigorous experiments that looked at 7 different characteristics (e.g. flower color, seed color and seed shape), each with 2 different traits (e.g. purple flower and white flowers).
He established true-breeding lines for each characteristic. For example, one line of plants would produce only purple flowers and another only white. He then crossed individuals with two different traits to see the resulting trait of the offspring over three generations.
In his observations, Mendel found that in the first generation of offspring only one of the traits was ever expressed (e.g. purple flowers). After crossing the first generation of offspring with each other, Mendel found that approximately 75% of the second generation inherited the same trait as their parents (i.e. the purple flowers of the first generation of offspring). The remaining 25% expressed the second trait of the original parents (e.g. white flowers), the trait that appeared to be lost in the first generation of offspring.
Following three generations of cross-breeding Mendel produced three significant conclusions regarding genetic inheritance. His first conclusion was that each trait is passed on unchanged to offspring via ‘units of inheritance’. These units are now known as ‘alleles’.
Mendel’s second conclusion, offspring inherit one allele from each parent for each characteristic. His third and final conclusion was that some alleles may not be expressed in an individual but can still be passed on to the next generation.
Mendel’s Laws of Inheritance
- Law of Segregation – The alleles for each character segregate during gamete production so that each gamete will only have one of the two alleles for each gene.
- Law of Independent Assortment – Pairs of alleles for each characteristic/gene segregate independently of each other.
Mendel’s work has been heavily built upon over the past 150 years and the field of genetics has come a long way since his pea experiments. His work set the foundation for our understanding of genetic inheritance in animals, plants and other complex organisms.
The process of inheritance is hugely important for understanding the complexity of life on Earth, in particular for its role in sexual reproduction and evolution. For this, Mendel’s contributions to science, biology and genetics are still widely recognized and applauded within the scientific community.
Alleles, genotype & phenotype
Alleles and genotypes are important foundations of genetics. An allele is a particular form of a gene and they are passed from parents to their offspring. A genotype is the combination of two alleles, one received from each parent.
The physical expression of a genotype is called the phenotype. The specific combination of the two alleles (the genotype) influences the physical expression (the phenotype) of the physical trait that the alleles carry information for. The phenotype can also be influenced by the environment
An allele is a particular form of one specific gene. When Gregor Mendel completed his experiments on peas he was crossing different traits of one characteristic, such as flower color.
Genetically, the variation in traits, e.g. purple flowers or white flowers, is caused by different alleles. In most cases in the plant and animal world, individuals have two alleles for each gene; one allele is inherited from their father and the second from their mother.
Depending on which alleles an individual has received will determine how their genes are expressed. For example, if two parents have blue eyes and pass the blue-eyed alleles onto their children, their children will also possess the alleles for blue eyes.
The genotype is the genetic combination of two alleles. If, for example, a child has received one brown-eye allele – represented by ‘B’ – and one blue-eye allele – represented by ‘b’ – then their genotype would be ‘Bb’. If, however, the child received two brown-eye alleles their genotype would be ‘BB’, and a child with two blue-eye alleles ‘bb’.
As previously mentioned, the brown-eye allele is dominant over the blue-eye allele so a child with the genotype ‘Bb’ would, in theory, have brown eyes, rather than blue or a mix between the two. Genotypes with two alleles that are the same, i.e. ‘BB’ and ‘bb’, are known as homozygous genotypes and genotypes with two different alleles are known as heterozygous genotypes.
The physical appearance of the genotype is called the phenotype. For example, children with the genotypes ‘BB’ and ‘Bb’ have brown-eye phenotypes, whereas a child with two blue-eye alleles and the genotype ‘bb’ has blue eyes and a blue-eye phenotype. The phenotype can also be influenced by the environment and sometimes certain alleles will be expressed in some environments but not in others. Therefore two individuals with the same genotype can sometimes have different phenotypes in they live in different environments.
- Gene – a section of DNA that contains the genetic material for one characteristic
- Allele – a particular form of a gene. One allele is received from each parent
- Genotype – the combination of the two alleles that are received from an individual’s parents
- Phenotype – the physical expression of the gene which is determined by both the genotype and the environment
- Heterozygous – a genotype with two different alleles
- Homozygous – a genotype with two of the same alleles
Last edited: 31 August 2020
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